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Medicine Grand Rounds - Multiple Sclerosis: Review and Role of MS Therapies

This presentation describes the pathophysiology of relapsing and progressive multiple sclerosis, illustrating that it is both an inflammatory and neurodegenerative disease state. Diagnosis is based on clinical presentation, and treatment options are often problematic as prognostication for disease progression is difficult. Treatment approaches are evolving with clinical trials underway; research is focused on slowing neurodegeneration and reducing or even halting the relapsing type of this disease.

Activity Details
Start Date: August 10, 2018
End Date: August 10, 2020
Link: View Presentation
  • Andrew D. Smith III, MD
    Assistant Professor of Neurology
    The Geisel School of Medicine
    Multiple Sclerosis Center
    Department of Neurology
    Dartmouth-Hitchcock Medical Center

    Andrew D. Smith III, MD is an Assistant Professor of Neurology in the Multiple Sclerosis Center at DHMC and at The Geisel School of Medicine. He completed his Neurology Residency and the Neuroimmunology and Experimental Therapeutics Fellowship at the University of Rochester. His expertise is in treatment of multiple sclerosis, autoimmune encephalitis and other neuroimmunological diseases. His clinical research efforts have been in cognition and clinical trial design in multiple sclerosis.

There is no fee for this activity, but to receive credit you must register online and complete the online Attestation and Evaluation form (you must register to access this form).

Learning Outcome

Participants will be able to review the current understanding of the pathophysiology, natural history and diagnostic criteria for diagnosis of multiple sclerosis. They will be able to discuss the efficacy of immunotherapies and current treatment approaches including the outcomes measures in clinical trials.


Dartmouth-Hitchcock is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Dartmouth-Hitchcock designates this enduring material for a maximum of 1 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Requirements for Successful Completion

In order to receive credit for this Continuing Medical Education (CME) activity, you must:

  • View the entire presentation
  • Complete the online Attestation of Attendance & Evaluation Form (you must register to access).
Speaker Disclosure

In accordance with the disclosure policy of Dartmouth-Hitchcock/Geisel School of Medicine at Dartmouth as well as standards set forth by the Accreditation Council on Continuing Medical Education and the Nursing Continuing Education Council standards set forth by the American Nurses Credentialing Center Commission on Accreditation, continuing medical education and nursing education activity director(s), planning committee member(s), speaker(s), author(s) or anyone in a position to control the content have been asked to disclose any financial relationship* they have to a commercial interest (any entity producing, marketing, re-selling, or distributing health care goods or services consumed by, or used on patients). Such disclosure is not intended to suggest or condone bias in any presentation, but is elicited to provide participants with information that might be of potential importance to their evaluation of a given activity.

The following Activity Physician Director(s), planning committee member(s), speaker(s), author(s) or anyone in a position to control the content for Multiple Sclerosis: Review and Role of MS Therapies (Medicine Grand Rounds) have reported the following financial interest or relationship* with various companies/organizations. The Activity Director and Planning Committee member roles were resolved by altering the individual’s control over content about the products or services of the commercial interest by the Associate Dean for CME and the Department of Medicine Chair. The Speaker role was validated by independent peer review by the Department of Medicine Chair and determined to be free of commercial bias. All potential conflict(s) were resolved.

* Kelly Kieffer, MD ~ her spouse is a consultant for OcculoBio. 

* Richard I. Rothstein, MD ~ has research support from Baranova (research grant to Dartmouth-Hitchcock Medical Center) and has other financial interest from Takeda. 

* Andrew D. Smith III, MD ~ is a consultant for Genzyme.

Other planning committee member(s), speaker(s), activity director(s), author(s) or anyone in a position to control the content for this program report no financial interest or relationship* with any company(ies) or organizations whose product may be germane to the content of their presentations.

*A “financial interest or relationship" refers to an equity position, receipt of royalties, consultantship, funding by a research grant, receiving honoraria for educational services elsewhere, or to any other relationship to a company that provides sufficient reason for disclosure, in keeping with the spirit of the stated policy.

Provider Contact Information

Provider contact information for questions regarding accreditation of the activity:
Center for Learning and Professional Development
Dartmouth-Hitchcock Medical Center

Type:     Internet Activity (Enduring Material)
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