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Medicine Grand Rounds - A Saga of Victims & Perpetrators in Therapeutics

Through case studies, clinical trials and in-vitro research, Dr. Lewis studies drug-drug interactions and how they inform optimal therapeutics and dosing, particularly in cancer therapy. He discusses how the study of individual pharmacogenetics can be additive to the understanding of pharmacokinetics and pharmacodynamics of drugs in formulating a treatment plan.

Activity Details

Start Date:  May 17, 2019
End Date:  May 17, 2021

You may claim CME credit for successful completion of this online course. In order to claim credit, you must follow these steps:

  1. Register for the learning activity by creating an account or logging in to your account.
  2. Click Continue to navigate to the Activity Material tab. Click View Presentation to view the recording.
  3. Return to this Activity page.
  4. Click Continue to navigate to the Evaluation tab; then click the Launch button to start the evaluation.
  5. Complete and Submit the evaluation and attestation form.

When the evaluation is submitted, you will be awarded credit. You may access your transcript for verification of participation at any time via Your Account. Need help? Visit the Support Page, send an Email, or call the Center for Learning and Professional Development at (603) 653-1234, Option 1.

  • Lionel D. Lewis, MA, MB, BCh, MD, FRCP
    Professor of Medicine and of Pharmacology and Toxicology
    The Geisel School of Medicine
    Dartmouth College

    Dr. Lionel Lewis is a clinician, laboratory researcher, and teacher at Dartmouth College and Dartmouth-Hitchcock. He is the current director of the Clinical Trials Office and facilitates Synergy for translational science. He is the Executive Director of the American Board of Clinical Pharmacology, and is a PI/Co –PI on many Phase-I and II studies of novel chemical entities for complex diseases including cancer, diabetes and HIV.

    Dr. Lewis received his BA and MA from Trinity College Cambridge, England and completed his clinical training in Medicine at the University Of Wales College Of Medicine, graduating Bachelor of Medicine /Bachelor of Surgery (MB.BCh) in 1977.  He gained his Doctorate in Medicine from the University of Wales and was a Fellow in Clinical Pharmacology at The Johns Hopkins Hospital.
Learning Outcome

Participants will be able to identify different models of drug-drug interaction studies and the types of information the data from these studies can convey, recognize how pharmacogenetics can influence drug-drug interactions, and appreciate how drug interactions mediated by pharmacogenetics can manifest in a phase III clinical trial.


Dartmouth-Hitchcock is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Dartmouth-Hitchcock designates this enduring material for a maximum of 1 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Requirements for Successful Completion

In order to receive credit for this Continuing Medical Education (CME) activity, you must:

  • View the entire presentation
  • Complete the online Attestation of Attendance & Evaluation Form (you must register to access).

In accordance with the disclosure policy of Dartmouth-Hitchcock/Geisel School of Medicine at Dartmouth as well as standards set forth by the Accreditation Council on Continuing Medical Education and the Nursing Continuing Education Council standards set forth by the American Nurses Credentialing Center Commission on Accreditation, continuing medical education and nursing education activity director(s), planning committee member(s), speaker(s), author(s) or anyone in a position to control the content have been asked to disclose any financial relationship* they have to a commercial interest (any entity producing, marketing, re-selling, or distributing health care goods or services consumed by, or used on patients). Such disclosure is not intended to suggest or condone bias in any presentation, but is elicited to provide participants with information that might be of potential importance to their evaluation of a given activity.

The following Activity Physician Director(s), planning committee member(s), speaker(s), author(s) or anyone in a position to control the content for A Saga of Victims & Perpetrators in Therapeutics (Medicine Grand Rounds) have reported the following financial interest or relationship* with various companies/organizations. The Activity Director and Planning Committee member roles were resolved by altering the individual’s control over content about the products or services of the commercial interest by the Associate Dean for CME and the Department of Medicine Chair. The Speaker role was resolved by validating the activity content through independent peer review by the Activity Director. All potential conflict(s) were resolved.

* Kelly Kieffer, MD ~ her spouse is a consultant for OcculoBio. 

* Richard I. Rothstein, MD ~ has research support from Baranova (research grant to Dartmouth-Hitchcock Medical Center) and has other financial interest from Allurion. 

* Lionel Lewis has grant/research support from Amgen, Bristol Meyers Squibb; is a consultant with Abbive, GSK, Novartis and Genetech and is a major stockholder with, GI Therapeutics and 7 Hills Pharma LLC.

Other planning committee member(s), speaker(s), activity director(s), author(s) or anyone in a position to control the content for this program report no financial interest or relationship* with any company(ies) or organizations whose product may be germane to the content of their presentations.

*A “financial interest or relationship" refers to an equity position, receipt of royalties, consultantship, funding by a research grant, receiving honoraria for educational services elsewhere, or to any other relationship to a company that provides sufficient reason for disclosure, in keeping with the spirit of the stated policy.

Provider Contact Information

Provider contact information for questions regarding accreditation of the activity:

Center for Learning and Professional Development
Dartmouth-Hitchcock Medical Center

Type:     Internet Activity (Enduring Material)
17 Registered Users