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Medicine Grand Rounds - ANCA Associated Vasculitis: Granulomatosis with Polyangiitis (GPA) and Microscopic Polyangiitis (MPA)

Dr. Arroyo discusses the clinical syndromes of AAV in comparison to other forms of vasculitis and identifies features that may be useful diagnostic clues. He discusses the current hypotheses regarding the underlying causes, and the immunopathogenic pathways that lead to manifestations in the affected tissues and organs in Granulomatous Polyangiitis (GPA) and Microscopic Polyangiitis (MPA). He emphasizes that treatment must be interdisciplinary because of the multi-system impact of these disorders. Efficacy of available treatments has improved dramatically over the last decades but in many cases AAV remains a challenge to manage long term.

Activity Details

Start Date:  July 19, 2019
End Date:  July 19, 2021

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  • Ramon A. Arroyo, MD
    Staff Rheumatologist
    San Antonio Military Medical Center
    Associate Professor of Medicine for the Uniformed Services University of the Health Sciences

    Dr. Arroyo graduated from the University of Puerto Rico Medical School on an Air Force Scholarship program and completed the Air Force rheumatology fellowship program in San Antonio, Texas where he practiced for twenty years.  While there, he was a Chairman, Program Director and Rheumatology consultant to the Air Force Surgeon General. Currently, he is a faculty member for the internal medicine residency and rheumatology fellowship programs at the San Antonio Military Medical Center. He is an Associate Professor of Medicine for the Uniformed Services University of the Health Sciences
Learning Outcome

Participants will be able to review the current classifications of vasculitis, review Anti-neutrophil cytoplasmic autoantibody associated vasculitis (AAV) epidemiology, pathogenesis and clinical manifestations, and discuss the current diagnostic tools and management for this complex syndrome.


Dartmouth-Hitchcock is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Dartmouth-Hitchcock designates this enduring material for a maximum of 1 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Requirements for Successful Completion

In order to receive credit for this Continuing Medical Education (CME) activity, you must:

  • View the entire presentation
  • Complete the online Attestation of Attendance & Evaluation Form (you must register to access).

In accordance with the disclosure policy of Dartmouth-Hitchcock/Geisel School of Medicine at Dartmouth as well as standards set forth by the Accreditation Council on Continuing Medical Education and the Nursing Continuing Education Council standards set forth by the American Nurses Credentialing Center Commission on Accreditation, continuing medical education and nursing education activity director(s), planning committee member(s), speaker(s), author(s) or anyone in a position to control the content have been asked to disclose any financial relationship* they have to a commercial interest (any entity producing, marketing, re-selling, or distributing health care goods or services consumed by, or used on patients). Such disclosure is not intended to suggest or condone bias in any presentation, but is elicited to provide participants with information that might be of potential importance to their evaluation of a given activity.

The following Activity Physician Director(s), planning committee member(s), speaker(s), author(s) or anyone in a position to control the content for ANCA Associated Vasculitis: Granulomatosis with Polyangiitis (GPA) and Microscopic Polyangiitis (MPA) (Medicine Grand Rounds) have reported the following financial interest or relationship* with various companies/organizations. The Activity Director and Planning Committee member roles were resolved by altering the individual’s control over content about the products or services of the commercial interest by the Associate Dean for CME and the Department of Medicine Chair. The speaker's conflict has been resolved by validating the activity content through independent peer review by Kelly Kieffer, MD. All potential conflict(s) were resolved.

* Kelly Kieffer, MD ~ her spouse is a consultant for OcculoBio. 

* Richard I. Rothstein, MD ~ has research support from Baranova (research grant to Dartmouth-Hitchcock Medical Center) and has other financial interest from Allurion. 

* Ramon A. Arroyo, MD ~ is on the Speakers Bureau for Genentech.

Other planning committee member(s), speaker(s), activity director(s), author(s) or anyone in a position to control the content for this program report no financial interest or relationship* with any company(ies) or organizations whose product may be germane to the content of their presentations.

*A “financial interest or relationship" refers to an equity position, receipt of royalties, consultantship, funding by a research grant, receiving honoraria for educational services elsewhere, or to any other relationship to a company that provides sufficient reason for disclosure, in keeping with the spirit of the stated policy.

Provider Contact Information

Provider contact information for questions regarding accreditation of the activity:

Center for Learning and Professional Development
Dartmouth-Hitchcock Medical Center

Type:     Internet Activity (Enduring Material)
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