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Medicine Grand Rounds - The ABCs (A3s) (and SP-C’s, HPS’s, RTELs) of Rare Lung Diseases: Insights for Understanding a Slightly Less Rare Lung Disease: Idiopathic Pulmonary Fibrosis

Dr. Beers describes the complex cellular pathways that lead to rare lung diseases in animal models and the clinical presentations of these rare conditions. By studying cell dysfunction in rare diseases, scientists are rethinking the pathogenesis of lung fibrosis. Specifically, aberrant wound healing of vulnerable epithelial cells after a viral load or smoking provides potential insights to disease pathogenesis, prevention, and treatment. Dr. Beers discusses the role of surfactant and AT2 cells and their impact on cell stress leading to inflammation and thickened lung interstitium, or fibrosis. This approach to understanding parenchymal lung diseases may lead to more targeted and effective therapeutic strategies.

Activity Details

Start Date:  October 11, 2019
End Date:  October 11, 2021

You may claim CME credit for successful completion of this online course. In order to claim credit, you must follow these steps:

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  5. Complete and Submit the evaluation and attestation form.

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  • Michael F. Beers, MD
    Robert L. Mayock & David A. Cooper Professor of Medicine
    Pulmonary and Critical Care Division 
    Perelman School of Medicine at the University of Pennsylvania
    Philadelphia, PA

    About our presenter: 
    Dr. Beers received his BA and MD from The University of Pennsylvania.  His post-graduate training has included an Internship, Residency, Pulmonary/Critical Care Fellowship, and bench research training in lung biology at the Institute for Environmental Medicine with Professor Aron B. Fisher, all at the University of Pennsylvania. He is currently an attending physician on the Chest Service and Medical Intensive Care Unit at the Michael Crescenz VA Medical Center and serves as the Director of the ILD Research Program at the Univ. of Pennsylvania. 

    Dr. Beers’ major research interests have included lung epithelial biology with a focus on surfactant protein metabolism, SP-C trafficking in health and disease, innate lung immunity from the perspective of lung injury/repair, and the role of epithelial dysfunction in the pathogenesis of Idiopathic Pulmonary Fibrosis and other parenchymal lung diseases.
Learning Outcome

Participants will be able to discuss the current state and unmet need for better Idiopathic Pulmonary Fibrosis (IPF) therapeutics, describe the molecular and cellular pathogenesis of IPF, and explain the role of epithelial dysfunction in the pathogenesis of interstitial lung disease and implications for current and future therapeutic strategies.


Dartmouth-Hitchcock is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Dartmouth-Hitchcock designates this enduring material for a maximum of 1 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Requirements for Successful Completion

In order to receive credit for this Continuing Medical Education (CME) activity, you must:

  • View the entire presentation
  • Complete the online Attestation of Attendance & Evaluation Form (you must register to access).

In accordance with the disclosure policy of Dartmouth-Hitchcock/Geisel School of Medicine at Dartmouth as well as standards set forth by the Accreditation Council on Continuing Medical Education and the Nursing Continuing Education Council standards set forth by the American Nurses Credentialing Center Commission on Accreditation, continuing medical education and nursing education activity director(s), planning committee member(s), speaker(s), author(s) or anyone in a position to control the content have been asked to disclose any financial relationship* they have to a commercial interest (any entity producing, marketing, re-selling, or distributing health care goods or services consumed by, or used on patients). Such disclosure is not intended to suggest or condone bias in any presentation, but is elicited to provide participants with information that might be of potential importance to their evaluation of a given activity.

The following Activity Physician Director(s), planning committee member(s), speaker(s), author(s) or anyone in a position to control the content for The ABCs (A3s) (and SP-C’s, HPS’s, RTELs) of Rare Lung Diseases: Insights for Understanding a Slightly Less Rare Lung Disease: Idiopathic Pulmonary Fibrosis (Medicine Grand Rounds) have reported the following financial interest or relationship* with various companies/organizations. The Activity Director and Planning Committee member roles were resolved by altering the individual’s control over content about the products or services of the commercial interest by the Associate Dean for CME and the Department of Medicine Chair. All potential conflict(s) were resolved.

* Kelly Kieffer, MD ~ her spouse is a consultant for OcculoBio. 

* Richard I. Rothstein, MD ~ has research support from Baranova (research grant to Dartmouth-Hitchcock Medical Center) and has other financial interest from Allurion. 

Other planning committee member(s), speaker(s), activity director(s), author(s) or anyone in a position to control the content for this program report no financial interest or relationship* with any company(ies) or organizations whose product may be germane to the content of their presentations.

*A “financial interest or relationship" refers to an equity position, receipt of royalties, consultantship, funding by a research grant, receiving honoraria for educational services elsewhere, or to any other relationship to a company that provides sufficient reason for disclosure, in keeping with the spirit of the stated policy.

Provider Contact Information

Provider contact information for questions regarding accreditation of the activity:

Center for Learning and Professional Development
Dartmouth-Hitchcock Medical Center

Type:     Internet Activity (Enduring Material)
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