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Medicine Grand Rounds - Pulmonary Fibrosis - How Epithelial Cells and Fibroblasts Use the Same Language to Drive Each Other Mad

Dr. Sheppard describes the in vivo biology of integrins and the roles they and their down-stream targets play in tissue fibrosis and cancer. He describes the phenomenon of integrin-mediated activation of latent TGFβ, the roles of integrins and TGFβ in multiple aspects of in vivo biology, and how dysfunctional epithelial cells and fibroblasts collaborate to drive pulmonary fibrosis. Dr. Sheppard’s work informs the research that supports pharmaceutical treatments that may help repair fibrotic lung tissue.

Activity Details

Start Date:  October 9, 2020
End Date: October 9, 2023

You may claim CME credit for successful completion of this online course. In order to claim credit, you must follow these steps:

  1. Register for the learning activity by creating an account or logging in to your account.
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  3. Return to this Activity page.
  4. Click Continue to navigate to the Evaluation tab; then click the Launch button to start the evaluation.
  5. Complete and Submit the evaluation and attestation form.

When the evaluation is submitted, you will be awarded credit. You may access your transcript for verification of participation at any time via Your Account. Need help? Visit the Support Page, send an Email, or call the Center for Learning and Professional Development at (603) 653-1234, Option 1.

Learning Outcome

Participants will be able to explain how dysfunctional epithelial cells and fibroblasts collaborate to drive pulmonary fibrosis and the role that members of the integrin family play in activating transforming growth factor beta signaling pathways to drive tissue fibrosis.

  • Dean Sheppard, MD
    Professor of Medicine
    Chief, Pulmonary, Critical Care, Allergy and Sleep
    Director, Lung Biology Center
    University of California, San Francisco

    About our presenter: 
    Dean Sheppard, MD is the Principal Investigator of the UCSF multidisciplinary training grant in lung disease for the past ten years, Division Chief of the Pulmonary, Critical Care and Allergy Division for the past eleven years and Lung Biology Center Director since 1986.

Dartmouth-Hitchcock is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Dartmouth-Hitchcock designates this enduring material for a maximum of 1 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Requirements for Successful Completion

In order to receive credit for this Continuing Medical Education (CME) activity, you must:

  • View the entire presentation
  • Complete the online Attestation of Attendance & Evaluation Form (you must register to access).

In accordance with the disclosure policy of Dartmouth-Hitchcock/Geisel School of Medicine at Dartmouth as well as standards set forth by the Accreditation Council on Continuing Medical Education and the Nursing Continuing Education Council standards set forth by the American Nurses Credentialing Center Commission on Accreditation, continuing medical education and nursing education activity director(s), planning committee member(s), speaker(s), author(s) or anyone in a position to control the content have been asked to disclose any financial relationship* they have to a commercial interest (any entity producing, marketing, re-selling, or distributing health care goods or services consumed by, or used on patients). Such disclosure is not intended to suggest or condone bias in any presentation, but is elicited to provide participants with information that might be of potential importance to their evaluation of a given activity.

The following Activity Physician Director(s), planning committee member(s), speaker(s), author(s) or anyone in a position to control the content have reported the following financial interest or relationship* with various companies/organizations. The Activity Director and Planning Committee member roles were resolved by altering the individual’s control over content about the products or services of the commercial interest by the Associate Dean for CME and the Department of Medicine Chair. The speaker conflict has been resolved by validating the activity content through independent peer review by Kelly Kieffer, MD. All potential conflict(s) were resolved.

* Kelly Kieffer, MD ~ her spouse is a consultant for OcculoBio. 

* Richard I. Rothstein, MD ~ has research support from Baranova (research grant to Dartmouth-Hitchcock Medical Center) and is on the Scientific Advisory Board for Allurion.

* Dean Sheppard, MD ~ has grant support/research support from Abbvie, Pliant, Pfizer and ShangPharma; he is a consultant for Pliant, Genentech, and Calico; he is a major stockholder in Pliant.

Other planning committee member(s), speaker(s), activity director(s), author(s) or anyone in a position to control the content for this program report no financial interest or relationship* with any company(ies) or organizations whose product may be germane to the content of their presentations.

*A “financial interest or relationship" refers to an equity position, receipt of royalties, consultantship, funding by a research grant, receiving honoraria for educational services elsewhere, or to any other relationship to a company that provides sufficient reason for disclosure, in keeping with the spirit of the stated policy.

Bibliographic References
  • See presentation for bibliographic sources to allow for further study.

Provider Contact Information

Provider contact information for questions regarding accreditation of the activity:

Center for Learning and Professional Development
Dartmouth-Hitchcock Medical Center

Type:     Internet Activity (Enduring Material)
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